The story is a continuation of the events depicted in Persona 4 Arena and begins the day after the previous game concludes, meaning Arena Ultimax is also set in May 2012.

The Midnight Channel is back on the air and once again broadcasts a strange advertisement for another fighting tournament christened P-1 Climax, also known as Operation: World Destruction, that shows members of the Investigation Team and the Shadow Operatives in combat. Just moments after this, Inaba is subject to a power outage and is engulfed by a bizarre red fog. Furthermore, figures that look suspiciously like Mitsuru Kirijo, Aigis and Akihiko Sanada being crucified are shown on TV. While the Investigation Team attempts to figure out what's going on, Junpei Iori and Rise Kujikawa becomes trapped in the red fog, while Labrys, Ken Amada, Koromaru and Yukari Takeba ride on a helicopter to see the fog engulf Inaba.Persona 4 Arena Ultimax is a fighting video game developed by Arc System Works and Atlus. It is the direct sequel to Persona 4 Arena, which is itself a follow-up to the role-playing game Persona 4. The game was originally released in Japanese arcades on November 28, 2013, and later ported to home consoles. Unlike the previous game, it is not region locked.